Nature Immunology
Broken hierarchies
Nature Immunology, Published online: 04 November 2022; doi:10.1038/s41590-022-01363-3Broken hierarchies
Nature Immunology
Fine-tuning <i>Notch1</i> by the stage-specific enhancer
Nature Immunology, Published online: 31 October 2022; doi:10.1038/s41590-022-01341-9DNSe, a double-negative thymocyte-specific Notch1 enhancer, is essential for activation of Notch1 expression and has a central role in T-cell-lineage c…
Nature Immunology
Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation
Nature Immunology, Published online: 31 October 2022; doi:10.1038/s41590-022-01343-7Farrar and colleagues perform an extensive analysis of Ncor1/2 function in B cell development. Loss of both genes results in defective pre-BCR signalin…
Nature Immunology
Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota
Nature Immunology, Published online: 31 October 2022; doi:10.1038/s41590-022-01345-5Durable antibody-mediated responses require long-lived plasma cells; however, these cells are difficult to identify. Hai Qi and colleagues now phenotyp…
Nature Immunology
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination
Nature Immunology, Published online: 31 October 2022; doi:10.1038/s41590-022-01329-5Sekaly and colleagues reveal a common pre-vaccination peripheral blood transcriptional signature that is predictive of antibody responses across 13 dif…
Nature Immunology
Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses
Nature Immunology, Published online: 31 October 2022; doi:10.1038/s41590-022-01328-6Pulendran and colleagues perform a comparative analysis of transcriptional responses of healthy young adults across 13 different vaccines. They find th…
Nature Immunology
A double-negative thymocyte-specific enhancer augments Notch1 signaling to direct early T cell progenitor expansion, lineage restriction and β-selection
Nature Immunology, Published online: 31 October 2022; doi:10.1038/s41590-022-01322-yNotch signaling is required for T cell development. Georgopoulos and colleagues identify an enhancer that specifically boosts Notch1 expression in earl…
Nature Immunology
The secret to longevity, plasma cell style
Nature Immunology, Published online: 31 October 2022; doi:10.1038/s41590-022-01340-wAn enduring antibody response is ultimately dependent on the generation and maintenance of long-lived plasma cells. New research describes the use of s…
Nature Immunology
CMTM4 is required for IL-17A signaling
Nature Immunology, Published online: 31 October 2022; doi:10.1038/s41590-022-01344-6We identified the transmembrane protein CMTM4 as an essential component of the IL-17 receptor. CMTM4 is required for membrane expression of IL-17 recep…
Nature Immunology
Divergent clonal differentiation trajectories of T cell exhaustion
Nature Immunology, Published online: 26 October 2022; doi:10.1038/s41590-022-01337-5Daniel, Yost, Hsiung, et al. generate a single-cell multiomic atlas of T cell exhaustion in chronic viral infection, which reveals molecular programs o…