Nature Immunology
Microbiota contributions
Nature Immunology, Published online: 03 January 2023; doi:10.1038/s41590-022-01407-8Microbiota contributions
Nature Immunology
Excess lipids on endosomes dictates NLRP3 localization and inflammasome activation
Nature Immunology, Published online: 03 January 2023; doi:10.1038/s41590-022-01364-2Diverse inflammasome stimuli recruit NLRP3 to dysfunctional endosomes via interactions with lipids that accumulate in excess on these organelles. Exces…
Nature Immunology
Tipping the balance in CD4<sup>+</sup> T cells
Nature Immunology, Published online: 03 January 2023; doi:10.1038/s41590-022-01389-7Signaling via T cell antigen receptors is diminished during aging. But paradoxically, CD4+ T cells from older adults tend to differentiate into effecto…
Nature Immunology
SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses
Nature Immunology, Published online: 29 December 2022; doi:10.1038/s41590-022-01385-xBoussiotis and colleagues show that the tyrosine phosphatase SHP-2 regulates the differentiation and antitumor function of monocytes downstream of the…
Nature Immunology
The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P<sub>2</sub> replenishment in response to TCR signaling during T cell development and survival
Nature Immunology, Published online: 29 December 2022; doi:10.1038/s41590-022-01372-2Weiss and colleagues identify a role for the endoplasmic reticulum-tethered PI transfer protein Nir3 in replenishing plasma membrane PIP2 levels in DN…
Nature Immunology
SREBP signaling is essential for effective B cell responses
Nature Immunology, Published online: 28 December 2022; doi:10.1038/s41590-022-01376-yThe regulatory protein SREBP is required for CD8+ T cell metabolic reprogramming after activation. Luo et al. demonstrate that stimulated B cells requ…
Nature Immunology
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells
Nature Immunology, Published online: 28 December 2022; doi:10.1038/s41590-022-01373-1Ha and colleagues show that loss of PD-1 expression on regulatory T cells in the tumor environment reduces their metabolic fitness and proliferative c…
Nature Immunology
Author Correction: The persistence of memory: defining, engineering, and measuring vaccine durability
Nature Immunology, Published online: 26 December 2022; doi:10.1038/s41590-022-01414-9Author Correction: The persistence of memory: defining, engineering, and measuring vaccine durability
Nature Immunology
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells
Nature Immunology, Published online: 23 December 2022; doi:10.1038/s41590-022-01366-0Stepanek and colleagues demonstrate that the LCK kinase associated with CD4 or CD8 co-receptors has kinase-dependent and kinase-independent roles in T…
Nature Immunology
An αvβ3 integrin checkpoint is critical for efficient T<sub>H</sub>2 cell cytokine polarization and potentiation of antigen-specific immunity
Nature Immunology, Published online: 22 December 2022; doi:10.1038/s41590-022-01378-wGata3 upregulation is required for TH2 cell polarization. McKenzie and colleagues find that integrin αvβ3 is upregulated by Gata3 and that this is cru…