Nature Immunology
A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function
Nature Immunology, Published online: 13 March 2023; doi:10.1038/s41590-023-01444-xLo and colleagues provide evidence for the TCR kinetic proofreading model by LAT Gly135Asp alteration to reveal functional consequences of altered kineti…