Nature Immunology
Tissue repairing cytokine
Nature Immunology, Published online: 22 May 2023; doi:10.1038/s41590-023-01535-9Tissue repairing cytokine
Nature Immunology
Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging
Nature Immunology, Published online: 22 May 2023; doi:10.1038/s41590-023-01519-9Linterman and colleagues examine germinal center formation in older individuals. They find that aged TFH cells have dysregulated CXCR4 expression, which ca…
Nature Immunology
Aberrant distribution of T<sub>FH</sub> cells in aged germinal centers reduces stromal cell function
Nature Immunology, Published online: 22 May 2023; doi:10.1038/s41590-023-01520-2The magnitude and quality of the germinal center response after vaccination decline with age. We found that T follicular helper (TFH) cells are enriched in…
Nature Immunology
Conserved stromal–immune cell circuits secure B cell homeostasis and function
Nature Immunology, Published online: 18 May 2023; doi:10.1038/s41590-023-01503-3Pikor et al. show that a set of conserved, bidirectional cues exchanged between fibroblastic reticular cells and immune cells sustain B cell niches, which …
Nature Immunology
PI16<sup>+</sup> reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches
Nature Immunology, Published online: 18 May 2023; doi:10.1038/s41590-023-01502-4De Martin, Ludewig and colleagues define the topology and molecular identity of human tonsillar stromal cells and show that PI16-expressing fibroblastic re…
Nature Immunology
CD4<sup>+</sup> T cell calibration of antigen-presenting cells optimizes antiviral CD8<sup>+</sup> T cell immunity
Nature Immunology, Published online: 15 May 2023; doi:10.1038/s41590-023-01517-xBedoui and colleagues describe a sequential process of integration of innate and CD40-delivered signals in APCs, which optimizes their capacity to drive an…
Nature Immunology
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology
Nature Immunology, Published online: 15 May 2023; doi:10.1038/s41590-023-01505-1Bacigaluppi and colleagues report that the accumulation of atypical mature and immature neutrophil subsets and a dysregulated emergency granulopoiesis resp…
Nature Immunology
Inflammaging aggravates stroke pathology
Nature Immunology, Published online: 15 May 2023; doi:10.1038/s41590-023-01516-yIn mice and humans, changes in neutrophil phenotypes and functionality during aging aggravate thromboinflammation in ischemic brain injury and determine th…
Nature Immunology
Author Correction: Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis
Nature Immunology, Published online: 09 May 2023; doi:10.1038/s41590-023-01525-xAuthor Correction: Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis
Nature Immunology
CD4<sup>+</sup> T cell memory
Nature Immunology, Published online: 08 May 2023; doi:10.1038/s41590-023-01510-4In this Review, Künzli and Masopust provide updates on our understanding of the biology of memory CD4+ T cells as well as key technological advances that f…