Nature Immunology
Editing cancer in vivo
Nature Immunology, Published online: 27 September 2024; doi:10.1038/s41590-024-01978-8Editing cancer in vivo
Nature Immunology
Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1<sup>+</sup> progenitor CD8<sup>+</sup> T cells to improve immunotherapy
Nature Immunology, Published online: 26 September 2024; doi:10.1038/s41590-024-01963-1TCF1+ progenitor-exhausted CD8+ T cell populations mediate durable antitumor immunity. Upon antigenic stimulation, effector T cells upregulate aerobi…
Nature Immunology
Recreating immune and epithelial interactions in organoids
Nature Immunology, Published online: 25 September 2024; doi:10.1038/s41590-024-01967-xA novel method that recreates human intestinal organoids containing viable tissue-resident memory T cells will facilitate the exploration of tissue–i…
Nature Immunology
IRF8 defines the epigenetic landscape in postnatal microglia, thereby directing their transcriptome programs
Nature Immunology, Published online: 23 September 2024; doi:10.1038/s41590-024-01962-2Saeki and colleagues show that IRF8 defines the epigenetic landscape in postnatal microglia, thereby directing their transcriptome programs.
Nature Immunology
IRF8 as durable architect of the microglial chromatin landscape
Nature Immunology, Published online: 23 September 2024; doi:10.1038/s41590-024-01965-zThe transcription factor IRF8 has an essential function in microglia during early postnatal development, adulthood and disease.
Nature Immunology
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
Nature Immunology, Published online: 17 September 2024; doi:10.1038/s41590-024-01961-3PD-1 is a critical modulator of CD8+ T cell activation and exhaustion. Sen and colleagues show that a cell-state-specific enhancer tunes PD-1 express…
Nature Immunology
Genomic map of the cellular composition of the tumor microenvironment
Nature Immunology, Published online: 17 September 2024; doi:10.1038/s41590-024-01964-0We integrated single-cell RNA-sequencing data to provide comprehensive profiles of the cellular composition of the tumor microenvironment and identif…
Nature Immunology
Author Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B
Nature Immunology, Published online: 17 September 2024; doi:10.1038/s41590-024-01984-wAuthor Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B
Nature Immunology
A B cell receptor variant confers evolutionary protection against pathogens
Nature Immunology, Published online: 17 September 2024; doi:10.1038/s41590-024-01953-3The G396R coding variant in IGHG1, which encodes membrane-bound IgG1 heavy chain, might have arisen within the Southeast Asian population as a potent…
Nature Immunology
The complexity of immune evasion mechanisms throughout the metastatic cascade
Nature Immunology, Published online: 16 September 2024; doi:10.1038/s41590-024-01960-4This Review on the interplay between the immune system and metastasis is part of our wider Series of Reviews on Cancer Immunology and Immunotherapy.