Nature Immunology, Published online: 05 January 2024; doi:10.1038/s41590-023-01717-5Ravichandran et al. performed a systems immunology study to profile the responses to pneumococcal vaccines in older adults. They identified distinct ba…
Nature Immunology, Published online: 05 January 2024; doi:10.1038/s41590-023-01737-1The effectiveness of pneumococcal vaccines declines with age for unknown reasons. We studied the responses of older adults to the 23-valent PPSV23 and …
Nature Immunology, Published online: 04 January 2024; doi:10.1038/s41590-023-01710-ySagar and colleagues provide a comprehensive single-cell multimodal landscape of γδ T cells in various mouse tissues, unveiling site-specific adaptatio…
Nature Immunology, Published online: 04 January 2024; doi:10.1038/s41590-023-01719-3Carnosine is a mobile buffering metabolite. Here the authors link carnosine accumulation, hypoxia and intracellular pH homeostasis in cancer cells as a…
Nature Immunology, Published online: 04 January 2024; doi:10.1038/s41590-023-01711-xAnrather and colleagues provide a longitudinal single-cell transcriptomic atlas of brain and mouse blood following stroke, describing brain-infiltratin…
Nature Immunology, Published online: 03 January 2024; doi:10.1038/s41590-023-01697-6Löhning and colleagues identify an alternative promoter for the Il1rl1 gene that drives IL-33 receptor expression in cytotoxic T cells and T-helper 1 c…
Nature Immunology, Published online: 03 January 2024; doi:10.1038/s41590-023-01691-yLenardo and colleagues identify a new human genetic disease, GISELL, whereby ceramide lipid homeostasis is disrupted, thereby altering T cell longevity…
Nature Immunology, Published online: 03 January 2024; doi:10.1038/s41590-023-01712-wTerminally differentiated plasma cells reside in multiple tissues to contribute to local immunity. Nutt and colleagues examined tissue-specific differe…
Nature Immunology, Published online: 03 January 2024; doi:10.1038/s41590-023-01706-8The alarmin IL-33 activates type 1 and type 2 immune cells via its receptor ST2 in a context-specific manner. We discovered a type 1 immunity-restricte…
Nature Immunology, Published online: 02 January 2024; doi:10.1038/s41590-023-01696-7Expressing chimeric antigen receptors (CARs) in macrophages has led to promising results in preclinical and clinical work. Now, induced pluripotent ste…