Nature Immunology, Published online: 25 October 2024; doi:10.1038/s41590-024-01990-yTertiary lymphoid structures (TLS) have different stages and cellular compositions in human tumors. New data are showing the effect of neoadjuvant immu…
Nature Immunology, Published online: 22 October 2024; doi:10.1038/s41590-024-01994-8In this Resource, Buckley and colleagues profile patients with Crohn’s disease and ulcerative colitis before and after adalimumab therapy. Specific pre…
Nature Immunology, Published online: 18 October 2024; doi:10.1038/s41590-024-01995-7Gámez-García et al. show that the deacetylase SIRT7 modulates the acetylation of Pax5 and its ability to repress alternate lineage programs and promote…
Nature Immunology, Published online: 16 October 2024; doi:10.1038/s41590-024-01987-7Using temporal and spatial tracking of allergen-specific T cells, we describe the gene regulatory networks that drive T helper 2 cells (TH2 cells) to d…
Nature Immunology, Published online: 16 October 2024; doi:10.1038/s41590-024-01991-xThe interplay of metabolites with epigenetic programs influences CD8+ T cell fate decisions. Here, Raychaudhuri et al. show that lactate-dependent hist…
Nature Immunology, Published online: 15 October 2024; doi:10.1038/s41590-024-01977-9The Irf8 +32-kb enhancer controls transcriptional autoactivation to generate ‘IRF8 on’ and ‘IRF8 off’ states that define type 1 conventional dendritic …
Nature Immunology, Published online: 15 October 2024; doi:10.1038/s41590-024-01993-9CAR-T cells are revolutionizing the treatment of cancer and other diseases. A latest iteration in development involves fusion with an antigen-based CAR…
Nature Immunology, Published online: 14 October 2024; doi:10.1038/s41590-024-01988-6Shen et al. identify a noncanonical role for the inflammasome protein NLR family CARD domain-containing protein 4 (NLRC4) to attenuate tumor developmen…
Nature Immunology, Published online: 14 October 2024; doi:10.1038/s41590-024-01988-6Shen et al. identify a noncanonical role for the inflammasome protein NLR family CARD domain-containing protein 4 (NLRC4) to attenuate tumor developmen…
Nature Immunology, Published online: 14 October 2024; doi:10.1038/s41590-024-01983-xA hallmark of post-viral lung disease, including post-acute sequelae of COVID-19, is dysplastic lung repair. CD8+ T cells contribute to aberrant repair…