Nature Immunology, Published online: 30 May 2024; doi:10.1038/s41590-024-01845-6Jacobsen and colleagues elucidate the nonhierarchical relationship between two types of stem cells: Vwf− hematopoietic stem cells that stably replenish all…
Nature Immunology, Published online: 30 May 2024; doi:10.1038/s41590-024-01833-wSchief and colleagues show that germline-targeting epitope scaffolds can elicit responses from rare broadly neutralizing antibody precursor B cells with pr…
Nature Immunology, Published online: 30 May 2024; doi:10.1038/s41590-024-01844-7Batista, Schief and colleagues use a series of germline-targeting immunogens in knock-in mice expressing heavy chain sequences derived from the HIV broadly…
Nature Immunology, Published online: 30 May 2024; doi:10.1038/s41590-024-01852-7Structure-guided protein design enables germline-targeting immunization strategies to generate broadly neutralizing antibodies against MPER, a region of th…
Nature Immunology, Published online: 29 May 2024; doi:10.1038/s41590-024-01836-7Segal and colleagues identify a population of immature neutrophils as having regenerative properties on injured neurons and being capable of inducing axon …
Nature Immunology, Published online: 29 May 2024; doi:10.1038/s41590-024-01848-3Sestan et al. find a conserved mechanism during systemic viral infection in which γδ T cells produce IFNγ to increase pancreatic insulin secretion, lowerin…
Nature Immunology, Published online: 29 May 2024; doi:10.1038/s41590-024-01849-2Immune cells coordinate β-cell insulin secretion to regulate glucose levels and promote type I interferon production to control systemic viral infection.
Nature Immunology, Published online: 28 May 2024; doi:10.1038/s41590-024-01859-0Immunosuppression is regulated by the circadian clock and can be leveraged to promote the efficacy of immune checkpoint inhibitor therapy.
Nature Immunology, Published online: 28 May 2024; doi:10.1038/s41590-024-01857-2Woolf and colleagues use single-cell transcriptomics to determine the gene signature of infiltrating immune cells and potential cell–cell interactions betw…
Nature Immunology, Published online: 27 May 2024; doi:10.1038/s41590-024-01834-9CAR T cells have shown great promise in treating some cancers and are now being applied to other diseases. Here the authors engineer mouse and human T cell…