Nature Immunology, Published online: 26 July 2024; doi:10.1038/s41590-024-01902-0Vinuesa et al. identify patients with systemic autoimmunity and a TNIP1 variant that result in dysregulated B cell function. Mice with the orthologous Tni…
Nature Immunology, Published online: 26 July 2024; doi:10.1038/s41590-024-01909-7Here, the authors show that there is a pretumorigenic TH17 subset in the intestines that can convert to being tumorigenic under the control of KLF6 and th…
Nature Immunology, Published online: 26 July 2024; doi:10.1038/s41590-024-01913-xTNIP1, a previously identified risk factor for autoimmunity, regulates mitochondrial autophagosomal trafficking. Missense mutations in TNIP1 disrupt this …
Nature Immunology, Published online: 24 July 2024; doi:10.1038/s41590-024-01907-9Why some individuals ‘resist’ infection with Mycobacterium tuberculosis (Mtb) has been an enigma. Enriched T cell phenotypes have now been linked to ‘resi…
Nature Immunology, Published online: 22 July 2024; doi:10.1038/s41590-024-01911-zThe G protein Gα13 is frequently lost in germinal center (GC) B cell-derived lymphomas. Mice that lack Gα13 exhibit increased proliferation of GC B cells …
Nature Immunology, Published online: 19 July 2024; doi:10.1038/s41590-024-01906-wImmunological imprinting early in life has been proposed to influence the risk of infection by influenza viruses later on — but hard evidence for this has…
Nature Immunology, Published online: 18 July 2024; doi:10.1038/s41590-024-01910-0Muppidi and colleagues show that loss of Gα13 drives B cell lymphomas preferentially in the mesenteric lymph nodes. They find that Gα13 is required to cou…
Nature Immunology, Published online: 18 July 2024; doi:10.1038/s41590-024-01896-9In this Review, the authors analyze functional and dysfunctional T cell features to make sense of cancer immunotherapy efficacy and how to improve it.
Nature Immunology, Published online: 18 July 2024; doi:10.1038/s41590-024-01908-8We constructed a humanized (THX) mouse by grafting non-γ-irradiated, genetically myeloablated immunodeficient mouse neonates with human cord blood CD34+ c…
Nature Immunology, Published online: 17 July 2024; doi:10.1038/s41590-024-01904-yWe performed transcriptional and chromatin accessibility profiling of TH17 cells to distinguish the pathways that regulate pathogenic versus non-pathogeni…