Nature Chemical Biology

Nature Chemical Biology, Published online: 29 July 2024; doi:10.1038/s41589-024-01696-0Under pressure

Nature Chemical Biology, Published online: 29 July 2024; doi:10.1038/s41589-024-01695-1A place to dock

Nature Chemical Biology, Published online: 29 July 2024; doi:10.1038/s41589-024-01668-4Characterization of DCAF16-based BRD4 molecular glue degraders revealed a trans-labeling mechanism termed ‘template-assisted covalent modification’,…

Nature Chemical Biology, Published online: 29 July 2024; doi:10.1038/s41589-024-01693-3Shu et al. showed that clustered regularly interspaced short palindromic repeat (CRISPR)-repressed toxins defend CRISPR–Cas against various anti-CRI…

Nature Chemical Biology, Published online: 29 July 2024; doi:10.1038/s41589-024-01649-7Two recent studies identify derivatives of (+)-JQ1, a non-degrading inhibitor of BET bromodomains, as molecular glues that recruit DCAF16 and DCAF11…

Nature Chemical Biology, Published online: 26 July 2024; doi:10.1038/s41589-024-01688-0β-Lactam antibiotics are detected by the sensor domain of BlaR in methicillin-resistant Staphylococcus aureus. A class of inhibitors has been develo…

Nature Chemical Biology, Published online: 26 July 2024; doi:10.1038/s41589-024-01689-zZhu et al. found that cytidine triphosphate usage in the Kennedy pathway for phospholipid synthesis influences nucleotide metabolism and redox balan…

Nature Chemical Biology, Published online: 26 July 2024; doi:10.1038/s41589-024-01690-6An examination of metabolic changes during B cell differentiation reveals that germinal center B cells selectively upregulate methylenetetrahydrofol…

Nature Chemical Biology, Published online: 26 July 2024; doi:10.1038/s41589-024-01691-5RAS proteins, central drivers of cancer, appeared ‘undruggable’ for almost 30 years. Here we provide a personal perspective on the effort leading to…

Nature Chemical Biology, Published online: 26 July 2024; doi:10.1038/s41589-024-01678-2A new study combines massively parallel assays, transcriptomics and biophysical modeling to provide a framework for analyzing the effects of compoun…