Nature Chemical Biology, Published online: 21 July 2022; doi:10.1038/s41589-022-01092-6Chemical probes are powerful tools for the discovery of ligand-binding and drug-target sites on proteins. A new software helps to profile their perf…
Nature Chemical Biology, Published online: 21 July 2022; doi:10.1038/s41589-022-01075-7Biomolecular condensates form and dissolve in response to a wide range of signals. A new study reports a solubility-based phosphoproteome-profiling …
Nature Chemical Biology, Published online: 15 July 2022; doi:10.1038/s41589-022-01112-5Author Correction: Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target
Nature Chemical Biology, Published online: 14 July 2022; doi:10.1038/s41589-022-01020-8A directed evolution approach delivers ribosomes with highly functional tethered subunits. Combining the decoding and peptidyl transferase activitie…
Nature Chemical Biology, Published online: 07 July 2022; doi:10.1038/s41589-022-01071-xFunctional screening of a large metagenomic library with a droplet microfluidics platform enabled the discovery of SN243, a bacterial β-glucuronidas…
Nature Chemical Biology, Published online: 07 July 2022; doi:10.1038/s41589-022-01072-wA combined screening and selection approach enables the evolution of the generalist transcription factor RamR into specific and sensitive biosensors…
Nature Chemical Biology, Published online: 07 July 2022; doi:10.1038/s41589-022-01099-zAuthor Correction: Making a 6mA demethylase
Nature Chemical Biology, Published online: 04 July 2022; doi:10.1038/s41589-022-01061-zThe marine compound microcolin B stimulates the Hippo pathway and selectively kills YAP-dependent cancer cells by inhibiting phosphatidylinositol tr…
Nature Chemical Biology, Published online: 04 July 2022; doi:10.1038/s41589-022-01066-8The Hippo pathway is a key regulator of tissue homeostasis, organ size and cancer. Identification of microcolin B and its analog molecules as Hippo …
Nature Chemical Biology, Published online: 04 July 2022; doi:10.1038/s41589-022-01048-wAldehyde dehydrogenase 1B1-specific small-molecule inhibitors are identified that block the growth of colon cancer spheroids and organoids and are s…