Nature Chemical Biology, Published online: 21 July 2022; doi:10.1038/s41589-022-01075-7Biomolecular condensates form and dissolve in response to a wide range of signals. A new study reports a solubility-based phosphoproteome-profiling …
Nature Chemical Biology, Published online: 21 July 2022; doi:10.1038/s41589-022-01065-9The discovery of a strained β-lactone electrophile that covalently targets a KRAS G12 somatic mutation and acylates the mutant serine to suppress on…
Nature Chemical Biology, Published online: 21 July 2022; doi:10.1038/s41589-022-01074-8pChem is a computational tool that provides a pipeline for performance assessment of chemoproteomic probes, with the ability to score the profiling …
Nature Chemical Biology, Published online: 21 July 2022; doi:10.1038/s41589-022-01062-yA combination of solubility proteome profiling with phosphoproteomics enables systematic analysis of the phosphorylation status of proteins in solub…
Nature Chemical Biology, Published online: 21 July 2022; doi:10.1038/s41589-022-01083-7Mutant-selective KRAS-targeting drugs hold great promise for the treatment of some of the most aggressive forms of cancer. Building on the breakthro…
Nature Chemical Biology, Published online: 15 July 2022; doi:10.1038/s41589-022-01112-5Author Correction: Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target
Nature Chemical Biology, Published online: 14 July 2022; doi:10.1038/s41589-022-01020-8A directed evolution approach delivers ribosomes with highly functional tethered subunits. Combining the decoding and peptidyl transferase activitie…
Nature Chemical Biology, Published online: 07 July 2022; doi:10.1038/s41589-022-01071-xFunctional screening of a large metagenomic library with a droplet microfluidics platform enabled the discovery of SN243, a bacterial β-glucuronidas…
Nature Chemical Biology, Published online: 07 July 2022; doi:10.1038/s41589-022-01072-wA combined screening and selection approach enables the evolution of the generalist transcription factor RamR into specific and sensitive biosensors…
Nature Chemical Biology, Published online: 07 July 2022; doi:10.1038/s41589-022-01099-zAuthor Correction: Making a 6mA demethylase