Nature Chemical Biology

Nature Chemical Biology, Published online: 22 August 2022; doi:10.1038/s41589-022-01126-zA versatile offense

Nature Chemical Biology, Published online: 18 August 2022; doi:10.1038/s41589-022-01128-xUsing structural and biochemical methods, Liang et al. revealed a C-terminal glutamine-end recognition mechanism of TRIM7 E3 ligases, which enable…

Nature Chemical Biology, Published online: 18 August 2022; doi:10.1038/s41589-022-01084-6The description of the cryo-EM structure of an orphan adhesion GPCR–Gs protein complex in apo state facilitates the screening and identification o…

Nature Chemical Biology, Published online: 16 August 2022; doi:10.1038/s41589-022-01129-wAuthor Correction: Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast

Nature Chemical Biology, Published online: 15 August 2022; doi:10.1038/s41589-022-01109-0A chemical genomics approach was used to identify regulators of drug sensitivity for pyrvinium, a cytotoxic agent with anti-cancer potential, reve…

Nature Chemical Biology, Published online: 15 August 2022; doi:10.1038/s41589-022-01091-7Metabolic labeling experiments on fermenting yeast revealed that ethanol is oxidized to acetaldehyde and acetyl-CoA and is also a major source of …

Nature Chemical Biology, Published online: 11 August 2022; doi:10.1038/s41589-022-01090-8Bicyclostreptins are peptide natural products in which a macrocyclic β-ether and a heterocyclic sp3–sp3 linkage between a backbone amide nitrogen …

Nature Chemical Biology, Published online: 11 August 2022; doi:10.1038/s41589-022-01108-1Elucidating the interactions between serum protein-bound nanoparticles and cell-surface receptors typically operates on a per protein–receptor int…

Nature Chemical Biology, Published online: 11 August 2022; doi:10.1038/s41589-022-01110-7Metabokiller is a novel, explainable AI-backed method for carcinogenicity prediction that leverages the biological and chemical properties associa…

Nature Chemical Biology, Published online: 11 August 2022; doi:10.1038/s41589-022-01093-5A combination of mass spectrometry, pooled genome screens and STRING analysis identifies key uptake mediating interactions between nanoparticle-ad…