Nature Chemical Biology

Nature Chemical Biology, Published online: 21 September 2022; doi:10.1038/s41589-022-01158-5Selective pH dependence

Nature Chemical Biology, Published online: 15 September 2022; doi:10.1038/s41589-022-01118-zCompound library screening combined with medicinal chemistry and structural biology approaches enables the development of potent and highly sel…

Nature Chemical Biology, Published online: 15 September 2022; doi:10.1038/s41589-022-01127-yPolyketides are assembled by modular polyketide synthases and undergo chemical tailoring reactions. A dehydratase domain variant catalyzes two …

Nature Chemical Biology, Published online: 15 September 2022; doi:10.1038/s41589-022-01145-wEnzymatically generated sulfane sulfur species called hydropersulfides terminate free radical chain reactions to prevent oxidative membrane dam…

Nature Chemical Biology, Published online: 12 September 2022; doi:10.1038/s41589-022-01121-4An RNA aptamer that selectively binds FAD over FADH2 shifted the reduction potential of the bound cofactor, similar to flavoproteins, and was s…

Nature Chemical Biology, Published online: 12 September 2022; doi:10.1038/s41589-022-01098-0Chemical proteomics identified covalent ligands targeting an isoform-restricted allosteric cysteine in JAK1. The compounds inhibit JAK1-depende…

Nature Chemical Biology, Published online: 12 September 2022; doi:10.1038/s41589-022-01120-5Isoform-selective inhibition of JAK kinases is of key interest in drug discovery. A novel pocket in the JAK pseudokinase domain was targeted by…

Nature Chemical Biology, Published online: 08 September 2022; doi:10.1038/s41589-022-01140-1SARS-CoV-2 spike-directed, non-neutralizing antibodies were converted into broad-spectrum inhibitors by conjugation to the SARS-CoV-2 receptor,…

Nature Chemical Biology, Published online: 05 September 2022; doi:10.1038/s41589-022-01119-yA tool kit to study bacterial efflux pumps and the movement of compounds across the cell envelope was developed enabling investigation of efflu…

Nature Chemical Biology, Published online: 01 September 2022; doi:10.1038/s41589-022-01113-4Engineering of a high-affinity Delta-like variant, named DeltaMAX, potently activates Notch signaling when provided in a bead-bound or cellular…