Nature Chemical Biology, Published online: 22 September 2022; doi:10.1038/s41589-022-01138-9Evernimicin, an antibiotic of the orthosomycin class, inhibits bacterial translation by preventing ribosomes from polymerizing specific amino a…
Nature Chemical Biology, Published online: 22 September 2022; doi:10.1038/s41589-022-01135-yBy inserting RNA-binding domains to an active-site-proximal loop amidst CRISPR–Cas, Yang, Song et al. generate variants with enhanced collatera…
Nature Chemical Biology, Published online: 22 September 2022; doi:10.1038/s41589-022-01130-3The combination of cryo-electron microscopy analysis with cell-signaling assays revealed promiscuous Gi/Gq coupling of somatostatin receptors a…
Nature Chemical Biology, Published online: 22 September 2022; doi:10.1038/s41589-022-01134-zChemigenetic combination of a synthetic ion-recognition motif and a protein-based fluorophore resulted in the development of calcium and sodium…
Nature Chemical Biology, Published online: 21 September 2022; doi:10.1038/s41589-022-01131-2Artificial intelligence (AI) is poised to transform therapeutic science. Therapeutics Data Commons is an initiative to access and evaluate AI c…
Nature Chemical Biology, Published online: 21 September 2022; doi:10.1038/s41589-022-01100-9A new method for controlling NTP-driven reactions in single-molecule experiments via the local generation of NTPs (LAGOON) markedly increases t…
Nature Chemical Biology, Published online: 21 September 2022; doi:10.1038/s41589-022-01144-xSingle-molecule methods are a powerful tool to study the kinetics of ATP-powered enzymes. A method that locally controls the generation of ATP …
Nature Chemical Biology, Published online: 21 September 2022; doi:10.1038/s41589-022-01156-7Redefining the off switch
Nature Chemical Biology, Published online: 21 September 2022; doi:10.1038/s41589-022-01158-5Selective pH dependence
Nature Chemical Biology, Published online: 21 September 2022; doi:10.1038/s41589-022-01155-8TIRs on my pillow