Nature Chemical Biology, Published online: 10 October 2022; doi:10.1038/s41589-022-01148-7Untargeted comparative metabolomics revealed serotonin biosynthesis and metabolism pathways in nonneuronal tissues that contribute to established…
Nature Chemical Biology, Published online: 10 October 2022; doi:10.1038/s41589-022-01152-xUnbiased metabolomics revealed the conversion of serotonin into N-acetylserotonin-derived glucosides by an intestinal carboxylesterase in Caenorh…
Nature Chemical Biology, Published online: 30 September 2022; doi:10.1038/s41589-022-01181-6Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine
Nature Chemical Biology, Published online: 29 September 2022; doi:10.1038/s41589-022-01149-6Aminoadamantane compounds, delivered to cells via binding to viroporin channels, induce S-nitrosylation of the ACE2 protein, inhibiting binding…
Nature Chemical Biology, Published online: 29 September 2022; doi:10.1038/s41589-022-01122-3Chemoproteomic analysis reveals that anti-infective bile acids directly bind and inactivate a transcriptional regulator of Salmonella virulence.
Nature Chemical Biology, Published online: 29 September 2022; doi:10.1038/s41589-022-01133-0The gut microbiota has a key role in protecting hosts from pathogens. A new study identified a gut microbiota-derived bile acid (chenodeoxychol…
Nature Chemical Biology, Published online: 26 September 2022; doi:10.1038/s41589-022-01116-1DNA-templated compound library screening and structure-guided hit optimization resulted in the identification of selective macrocyclic inhibito…
Nature Chemical Biology, Published online: 26 September 2022; doi:10.1038/s41589-022-01137-wMukherjee et al. report that AcrIF24 is an Acr-Aca fusion protein that inhibits the Csy complex and suppresses transcription from the acrIF23–a…
Nature Chemical Biology, Published online: 26 September 2022; doi:10.1038/s41589-022-01139-8Cryo-EM structures of the mouse TRPV2 channel, combined with electrophysiology and simulations, reveal that endogenous cholesterol binds to the…
Nature Chemical Biology, Published online: 26 September 2022; doi:10.1038/s41589-022-01136-xAn INSPIRE platform for therapeutic regulators and sensors, based on split human domains binding physiological or clinically approved compounds…