Nature Chemical Biology

Nature Chemical Biology, Published online: 20 October 2022; doi:10.1038/s41589-022-01188-zProviding inclusivity

Nature Chemical Biology, Published online: 20 October 2022; doi:10.1038/s41589-022-01185-2Food from air

Nature Chemical Biology, Published online: 17 October 2022; doi:10.1038/s41589-022-01147-8A substrate-guided design strategy generated highly potent inhibitors of the biosynthesis of the genotoxin colibactin by human gut bacteria. Thes…

Nature Chemical Biology, Published online: 17 October 2022; doi:10.1038/s41589-022-01142-zStructure and mutagenesis of the colibactin-activating peptidase ClbP reveals a dimer with a substrate-binding transmembrane domain and a conserv…

Nature Chemical Biology, Published online: 13 October 2022; doi:10.1038/s41589-022-01150-zA small molecule was developed that disrupted the lipid–SH2 domain interaction of the spleen tyrosine kinase (Syk), suppressed oncogenic activiti…

Nature Chemical Biology, Published online: 13 October 2022; doi:10.1038/s41589-022-01117-0The structure of fungal sterol receptor Upc2 reveals ligand specificity and mechanism of transcriptional activation contributing to azole resista…

Nature Chemical Biology, Published online: 13 October 2022; doi:10.1038/s41589-022-01143-yThe fungal sterol receptor and transcription factor Upc2 activates the transcription of ergosterol biosynthesis genes in response to ergosterol d…

Nature Chemical Biology, Published online: 13 October 2022; doi:10.1038/s41589-022-01161-wProstate tumors, resistant to current antiandrogen therapies, represent a serious clinical challenge. A new report identifies androgen-receptor-d…

Nature Chemical Biology, Published online: 13 October 2022; doi:10.1038/s41589-022-01163-8A precise adenine base editor variant, ABE9, was developed to generate single adenine transition at pathogenic homopolymeric adenine sites with m…

Nature Chemical Biology, Published online: 13 October 2022; doi:10.1038/s41589-022-01151-yPhase separation of androgen receptor underlies mutation-mediated antiandrogen resistance. A phenotypic screen enabled the discovery of ET516, wh…