Nature Chemical Biology, Published online: 03 November 2022; doi:10.1038/s41589-022-01177-2Coupling haploid genetics with deep scanning mutagenesis, Hanzl et al. identified functional hotspots in E3 ubiquitin ligases that are selective…
Nature Chemical Biology, Published online: 31 October 2022; doi:10.1038/s41589-022-01172-7Coenzyme A (CoA) is a ubiquitous and essential cofactor. A biosensor for visualizing cytosolic and mitochondrial CoA in living cells was develope…
Nature Chemical Biology, Published online: 31 October 2022; doi:10.1038/s41589-022-01178-1Akizuki et al. reveal an unexpected role for K63-linked ubiquitin chains and the E2 enzyme UBE2N in degrader-induced degradation of cIAP1 through…
Nature Chemical Biology, Published online: 27 October 2022; doi:10.1038/s41589-022-01168-3Murray et al. identified and characterized a small-molecule inhibitor of human COQ8A, which belongs to the UbiB protein family and is essential f…
Nature Chemical Biology, Published online: 27 October 2022; doi:10.1038/s41589-022-01173-6The cryo-EM structures of MRGPRX1–Gq complexes are reported, which revealed the activation and allosteric modulation mechanism of human MRGPRX1 r…
Nature Chemical Biology, Published online: 27 October 2022; doi:10.1038/s41589-022-01166-5Fan et al. report a potent and subtype-selective TRPV3 antagonist, Trpvicin, and reveal its binding sites and mode of action for TRPV3 inhibition…
Nature Chemical Biology, Published online: 27 October 2022; doi:10.1038/s41589-022-01170-9Velcrins kill cancer cells by inducing complex formation between PDE3A and SLFN12, upregulating SLFN12 RNase activity. Activated SLFN12 specifica…
Nature Chemical Biology, Published online: 24 October 2022; doi:10.1038/s41589-022-01154-9Glutamine synthetase is the only enzyme that synthesizes glutamine in mammals. In vivo metabolomics showed that glutamine synthetase utilizes met…
Nature Chemical Biology, Published online: 24 October 2022; doi:10.1038/s41589-022-01141-0YcaO enzymes carry out diverse tailoring reactions of peptide-derived natural products, such as formation of rings and incorporation of sulfur, b…
Nature Chemical Biology, Published online: 24 October 2022; doi:10.1038/s41589-022-01159-4Mitochondrial ferredoxins FDX1 and FDX2 are assigned to specifically donate electrons to steroidogenesis, Fe–S protein biogenesis, heme a formati…