Nature Chemical Biology, Published online: 05 December 2022; doi:10.1038/s41589-022-01200-6Bacteria utilize stringent factors to metabolize the nucleotide alarmone guanosine tetra-/pentaphosphate, or (p)ppGpp, for stress adaptation. No…
Nature Chemical Biology, Published online: 05 December 2022; doi:10.1038/s41589-022-01200-6Bacteria utilize stringent factors to metabolize the nucleotide alarmone guanosine tetra-/pentaphosphate, or (p)ppGpp, for stress adaptation. No…
Nature Chemical Biology, Published online: 05 December 2022; doi:10.1038/s41589-022-01183-4Inspired by nature, a synthetic carbon fixation cycle builds complex molecules directly from CO2. Building metabolism from the ground up require…
Nature Chemical Biology, Published online: 05 December 2022; doi:10.1038/s41589-022-01183-4Inspired by nature, a synthetic carbon fixation cycle builds complex molecules directly from CO2. Building metabolism from the ground up require…
Nature Chemical Biology, Published online: 28 November 2022; doi:10.1038/s41589-022-01202-4The human gut Bifidobacterium longum can use host N-glycans as carbon and energy sources via a specific and cooperative multienzymatic system.
Nature Chemical Biology, Published online: 28 November 2022; doi:10.1038/s41589-022-01199-wHigh-mannose N-glycans are common post-translational modifications that occur on many proteins. The mechanism by which these high-mannose N-glyc…
Nature Chemical Biology, Published online: 28 November 2022; doi:10.1038/s41589-022-01201-5Major hurdles remain in understanding the mechanisms of multidrug resistance (MDR) protein efflux. A new study uses deep mutational scanning of …
Nature Chemical Biology, Published online: 28 November 2022; doi:10.1038/s41589-022-01205-1Deep mutational scanning revealed the drug efflux activity profile of more than 1,430 single variants, enabling the identification of critical r…
Nature Chemical Biology, Published online: 21 November 2022; doi:10.1038/s41589-022-01208-yCryo-EM structures of µ-opioid receptor complexes with two agonists coupled to molecular dynamics simulations and functional assays highlight di…
Nature Chemical Biology, Published online: 21 November 2022; doi:10.1038/s41589-022-01193-2Homotrimeric DARPin molecules neutralize SARS-CoV-2 variants of concern by targeting a critical ACE2-binding interface.