Nature Chemical Biology, Published online: 13 June 2024; doi:10.1038/s41589-024-01645-xThe inaugural CRISPR-based drug Casgevy has been approved by several medical agencies, with other CRISPR-based therapies currently in clinical trial…
Nature Chemical Biology, Published online: 10 June 2024; doi:10.1038/s41589-024-01650-0An end-to-end pipeline generates the optimal copy number combination of genes in a biosynthetic pathway for chromosomal integration to engineer high…
Nature Chemical Biology, Published online: 07 June 2024; doi:10.1038/s41589-024-01640-2The kinesin-1 motor protein accesses open active and closed autoinhibited states. These states are regulated by a flexible elbow within a complex co…
Nature Chemical Biology, Published online: 06 June 2024; doi:10.1038/s41589-024-01652-yFluorogenic RNA aptamers have previously been developed to enhance RNA imaging. We determined the tertiary complex structures of a newly discovered …
Nature Chemical Biology, Published online: 04 June 2024; doi:10.1038/s41589-024-01630-4Toxic small alarmone synthetase (toxSAS) enzymes are toxic effectors of certain toxin–antitoxin modules, involved in phage defense and secretion sys…
Nature Chemical Biology, Published online: 03 June 2024; doi:10.1038/s41589-024-01636-yEnediyne natural products are potent antitumor antibiotics but the biosynthesis of their 1,5-diyne-3-ene core has remained enigmatic for decades. He…
Nature Chemical Biology, Published online: 03 June 2024; doi:10.1038/s41589-024-01637-xTo understand the complex dynamics and diverse functions of RNA, robust technologies for labeling and imaging RNA are highly desirable. A newly deve…
Nature Chemical Biology, Published online: 03 June 2024; doi:10.1038/s41589-024-01626-0A de novo-designed protein that precisely assembles a chlorophyll dimer has been developed. The design matches the conformation of the native ‘speci…
Nature Chemical Biology, Published online: 31 May 2024; doi:10.1038/s41589-024-01631-3We developed a rational approach to design peptide-based covalent inhibitors and coupled the inhibitors with antibodies for cell-specific delivery. W…
Nature Chemical Biology, Published online: 30 May 2024; doi:10.1038/s41589-024-01633-1Huang et al. report the tertiary structure of a small monomeric fluorogenic RNA aptamer named Clivia, characterized by a large Stokes shift, revealin…