Nature Chemical Biology, Published online: 21 June 2024; doi:10.1038/s41589-024-01638-wThis Perspective proposes practical guidance to the application of AlphaFold2 for structure prediction of different classes of proteins including ri…
Nature Chemical Biology, Published online: 21 June 2024; doi:10.1038/s41589-024-01614-4Chemical, genetic and proteomic approaches were used to elucidate the mode of action of orpinolide, a withanolide-inspired OSBP inhibitor, revealing…
Nature Chemical Biology, Published online: 21 June 2024; doi:10.1038/s41589-024-01653-xOxybipins were identified as potent selective inhibitors of oxysterol-binding protein, promoting Golgi fragmentation, inhibiting retrograde traffick…
Nature Chemical Biology, Published online: 21 June 2024; doi:10.1038/s41589-024-01656-8Identifying the protein component of calcium signaling in specific subcellular regions presents considerable challenges. Researchers have now succes…
Nature Chemical Biology, Published online: 21 June 2024; doi:10.1038/s41589-024-01639-9Natural products and synthetic bifunctional molecules enable the development of new chemical probes that target oxysterol-binding protein (OSBP), a …
Nature Chemical Biology, Published online: 20 June 2024; doi:10.1038/s41589-024-01642-0An efficient computational pipeline starting from validated peptide assemblies has been used to design two families of α-helical barrel proteins wit…
Nature Chemical Biology, Published online: 19 June 2024; doi:10.1038/s41589-024-01635-zA tryptophan metabolite was identified that acts systemically to promote defense against bacterial infection by targeting kainate receptors (KARs), …
Nature Chemical Biology, Published online: 19 June 2024; doi:10.1038/s41589-024-01643-zAn in vivo chemical screen has uncovered a potential role for a tryptophan metabolite in promoting host survival during bacterial infections through…
Nature Chemical Biology, Published online: 18 June 2024; doi:10.1038/s41589-024-01654-wA photochromic dimerizer was developed for light-controlled reversible and quantitative regulation of intracellular protein localization, enabling o…
Nature Chemical Biology, Published online: 18 June 2024; doi:10.1038/s41589-024-01641-1Biological nitrogen fixation requires low-potential electrons from ferredoxin or flavodoxin. Here the authors show how the soil diazotroph Azotobact…