Nature Chemical Biology, Published online: 05 December 2025; doi:10.1038/s41589-025-02083-zA deep-learning-based de novo design strategy was developed that enables simultaneous scaffolding of three distinct epitopes derived from respir…
Nature Chemical Biology, Published online: 01 December 2025; doi:10.1038/s41589-025-02078-wRadical FeII/α-ketoglutarate-dependent halogenases are promising biocatalysts for C(sp3)–H functionalization, which can replace a substrate H at…
Nature Chemical Biology, Published online: 28 November 2025; doi:10.1038/s41589-025-02084-yThe function of membrane proteins is dependent on the lipid environment, but whether this is due to high-affinity, ligand-like linkage is unclea…
Nature Chemical Biology, Published online: 27 November 2025; doi:10.1038/s41589-025-02080-2A recent study developed a refined photocatalytic labeling-based method to capture and sequence physically interacting cells in situ and discove…
Nature Chemical Biology, Published online: 21 November 2025; doi:10.1038/s41589-025-02058-0Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). Wing, Fung and Kwanten et al. found that selinexor mediates …
Nature Chemical Biology, Published online: 21 November 2025; doi:10.1038/s41589-025-02072-2Research shows how small nuclear RNAs act as a cellular GPS to guide endogenous RNA-modifying enzymes to their targets for site-specific RNA edi…
Nature Chemical Biology, Published online: 21 November 2025; doi:10.1038/s41589-025-02079-9How biogenic crystals form within cells despite their building blocks being water insoluble is a conundrum. Now, it has been shown that zebrafis…
Nature Chemical Biology, Published online: 21 November 2025; doi:10.1038/s41589-025-02059-zMolecular glue degraders induce or stabilize interactions between E3 ligases and target proteins. Beyond compound-induced, direct interactions, …
Nature Chemical Biology, Published online: 04 April 2025; doi:10.1038/s41589-025-01866-8Native top-down proteomics reveals epidermal growth factor receptor–estrogen receptor-alpha (EGFR–ER) signaling crosstalk in breast cancer cells an…
Nature Chemical Biology, Published online: 02 April 2025; doi:10.1038/s41589-025-01867-7Evaluating the off-target effect is crucial for ensuring the safety of CRISPR–Cas9-based technologies. Duan, Gao and Zhang et al. developed TOPO-se…