Centre for Cognitive Science

Pre- and Postsynaptic MEF2C Promotes Experience-Dependent, Input-Specific Development of Cortical Layer 4 to Layer 2/3 Excitatory Synapses and Regulates Activity-Dependent Expression of Synaptic Cell Adhesion Molecules

Experience- and activity-dependent transcription is a candidate mechanism to mediate development and refinement of specific cortical circuits. Here, we demonstrate that the activity-dependent transcription factor myocyte enhancer factor 2C (MEF2C) is …

By Putman, J. N., Watson, S. D., Zhang, Z., Khandelwal, N., Kulkarni, A., Gibson, J. R., Huber, K. M., ago

Spatiotemporal Neural Network for Sublexical Information Processing: An Intracranial SEEG Study

Words offer a unique opportunity to separate the processing mechanisms of object subcomponents from those of the whole object, because the phonological or semantic information provided by the word subcomponents (i.e., sublexical information) can confl…

By Zhao, C., Liu, Y., Zeng, J., Luo, X., Sun, W., Luan, G., Liu, Y., Zhang, Y., Shi, G., Guan, Y., Han, Z., ago

G-Protein Signaling in Alzheimer’s Disease: Spatial Expression Validation of Semi-supervised Deep Learning-Based Computational Framework

Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer’s disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide o…

By Zhang, D. F., Penwell, T., Chen, Y.-H., Koehler, A., Wu, R., Nik Akhtar, S., Lu, Q., ago